Заключение
Наш общий вывод состоит в том, что главная функция парадоксального сна — восстановление достаточного уровня поисковой активности в последующем бодрствовании. Во время бодрствования поисковая активность в нормальном состоянии соответствует требованиям окружающей среды, адекватна целям и решаемым задачам, и адекватно модулируется моноаминами мозга. Отказ от поиска во время бодрствования сопровождается сниженной активностью большинства моноаминовых систем мозга, особенно норадреналина мозга. В нормальном, функционально достаточном парадоксальном сне поисковая активность поддерживается ничем не ограниченной активностью мозговой дофаминовой системы (что делает поисковую активность в сновидениях чрезвычайно подвижной и обеспечивает ее полное восстановление). В то же время парадоксальный сон обеспечивает условия для того, чтобы происходила ресенсибилизация норадреналовых постсинаптических рецепторов, которая является важной для продолжения поисковой активности при последующем бодрствовании.
Данная модель помогает объяснять много спорных и противоречивых данных о связях парадоксального сна и моноаминов мозга.
Литература
Adrien J, Dugovic CH, Martin P. Sleep wakefulness patterns in helpless rats. Physiol Behav 1991; 49:257-262.
Asakura W, Matsumoto K, Ohta H et al. Effect of alpha2-adrenergic drugs on REM sleep deprivation—induced increase in swimming activity. Pharmacol Biochem Behav 1993; 46:111-115.
Asakura W, Matsumoto K, Ohta H et al. Monoamine depletion attenuates the REM sleep deprivation-induced increase in clonidine response in the forced swimming test. Pharmacol Biochem Behav 1994; 49:79-84.
Asakura W, Matsumoto K, Jhta H et al. Involvement of dopamine D2 receptor mechanism in the REM sleep deprivation-induced increase in swimming activity in the forced swimming test. Pharmacol Biochem Behav 1994; 48:43-46.
Asakura W, Matsumoto K, Watanabe H. REM sleep deprivation treatment enhances the effect of clozapine in the forced swimming test. Gen Pharmac 1995; 26:1225-1228.
Baldessarini RJ. Chemotherapy in psychiatry: Principles and practice. 2nd ed. Cambridge: Harvard University Press, 1985.
Benington JH, Heller HC. Monoaminergic and cholinergic modulation of REM-sleep timing in rats. Brain Res 1995; 681:141-146.
Benjamin J, Patterson Ch, Greenberg BD et al. Population and familial association between the D4 dopamine receptor gene and measures of novelty seeking. Nat Genet 1996; 12:81-84.
Beutler L, Ware J, Karacan I et al. Differentiating psychological characteristics of patients with sleep apnea and narcolepsy. Sleep 1981; 4:39-47.
Cloninger CB, Adolfsson R, Svrakic NM. Mapping genes for human personality. Nat Genet 1996; 12:3-4.
Coble PA, Kupfer DJ, Shaw DH. Distribution of REM latency in depression. Biol Psychiatry 1981; 16:453-466.
Cohen RM, Pickar D, Garnett D et al. REM sleep suppression induced by selective monoamine oxidase inhibitors. Psychopharmacology (Berl) 1982; 78:137-140.
Darchia N, Oniani T, Gvilia I et al. Analysis of competitive interrelationship of wakefulness and paradoxical sleep using two different methods of paradoxical sleep deprivation. Abstracts of the 3rd International Congress of WFSRS. Dresden, 1999; 521.
Dement WC, Mitler MM, Henricksen SJ. Sleep changes during
chronic administration of parachlorphenylalanine. Rev Can Biol 1972; 31:69-75.
Ebstein RP, Novick O, Umansky R et al. Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of novelty seeking. Nat Genet 1996; 12:78-80.
Everson CA. Functional consequences of sustained sleep deprivation in the rat. Behav Brain Res 1995; 69:43-54.
Feng P, Ma Y. Clomipramine suppresses postnatal REM sleep without increasing wakefulness: Implications for the production of depressive behaviors. Sleep 2002; 25:177-184.
Fornal C, Auerbach S, Jacobs BL. Activity of serotonin-containing neurons in nucleus raphe magnus in freely moving cats. Exp Neurol 1985; 88:590-608.
Gaillard JM. Brain catecholaminergic activity in relation to sleep. In: Priest RG, Pletscher A, Ward J, eds. Sleep Research: Proceedings of the Northern European Symposium on Sleep Research. Basle: 1979:35-41.
Gillin JC, Wyatt RJ, Fram D et al. The relationship between changes in REM sleep and clinical improvement in depressed patients treated with amitriptyline. Psychopharmacol (Berlin) 1978; 59:267-272.
Gonzales MM, del C, Valatx JL et al. Role of the locus coeruleus on the mechanism of the sleep rebound. J Sleep Res 1994; 3(Suppl 1):92.
Gonzalez MM, del C, Debilly G et al. Sleep increase after immobilization stress: Role of the noradrenergic locus coeruleus system in rat. Neuroscience Letters 1995; 202:5-8.
Gottesmann C. The neurochemistry of waking and sleeping mental activity: The disinhibition-dopamine hypothesis. Psychiatry and Clinical Neurosciences 2002; 56:345-354.
Greenberg R. Where is the forest? Where is the dream? Behavioral and Brain Sciences 2000; 23:943-945.
Greenberg R, Pearlman CH. The private language of the dream. In: J Natterson, ed. The dream in clinical practice. New York Aronson, 1980; 85-96.
Gvilia I, Oniani T, Darchia N et al. Analysis of the effect of total sleep deprivation in rats. Abstracts of the 3rd International Congress of WFSRS. Dresden, 1999:533.
Hartmann E. The Functions of Sleep. New Hawen, CT: Yale University Press, 1973.
Hartmann E, Chung R, Draskoczy PR et al. Effects of 6-hydroxydopamine on sleep in the rat. Nature (bond.) 1971; 233:425-427.
Hartmann E, Russ D, Oldfield M et al. Dream content: Effects of L-DOPA Sleep Research 1980; 9:153.
Hobson JA, McCarley RW, Nelson JP Location and spike-train characteristics of cells in anterodorsal pons having selective decreases in firing in rat during desynchronized sleep. J Neurophysiol 1983; 50:770-783.
Jobert M, Jahnig P, Schulz H. Effect of two antidepressant drugs on REM sleep and EMG activity during sleep. Neuropsychobiology 1999; 39:101-109.
Jones HM, Pilowsky LS. Dopamine and antipsychotic drug action revisited. British Journal of Psychiatry 2002; 181:271-275.
Jones BE, Harper ST, Halaris AE. Effects of locus coeruleus lesions upon cerebral monoamine content, sleep wakefulness states and the response to amphetamine in the cat. Brain Res 1977; 124:473-496.
Kafi S, Bouras C, Constantinidis J et al. Paradoxical sleep and brain catecholamines in the rat after single and repeated administration of alpha-methyl-parathyrosine. Brain Res 1977; 135:123-134.
Kamamori N, Sakai K, Jouvet M. Neuronal activity specific to paradoxical sleep in the ventromedial medullary reticular formation of unrestrained cats. Brain Res 1980; 189:251-255.
Kapur Sh. Psychosis as a state of aberrant salience: A framework linking biology phenomenology and pharmacology in schizophrenia. American J Psychiatry 2003; 160:13-23.
Kinai T, Scerb JC. Mesencephalic reticular activating system and cortical acetylcholine output. Nature 1965; 205:80-82.
Kramer M. The selective mood regulatory function of dreaming: An update and revision. In: Moffitt A, Kramer M, Hoffmann R, eds. The function of dreaming. New York, Albany: State University of New York Press, 1993:139-196
Kuiken D, Sikora S. The impact of dreams on waking thoughts and feelings. In: Moffitt A, Kramer M, Hoffmann R, eds. The function of dreaming. New York: States University of New York Press, 1993:419-476.
Kupfer DJ, Ulrich RF, Coble PA et al. The application of automated REM and slow wave sleep analysis (normal and depressives). Psychiatr Res 1984; 13:325-334.
Landolt HP, de Boer LP. Effect of chronic phenelzine treatment on REM sleep: Report of three patients. Neuropsychopharmacology 2001; 25:S63-67.
McGinty DJ, Harper KM. Dorsal raphe neurons depression of firing during sleep in cats. Brain Res 1976; 101:569-575.
Mendelson WB, Gillin JCh, Wyatt RJ. Human sleep and its disorders. New York: Plenum Press, 1977.
Mirmiran M, Van de Poll NE, Corner MA. Suppression of active sleep by chronic treatment with chlorimipramine during early postnatal development: Effect upon adult sleep and behavior in the rat. Brain Res 1981; 204:129-146.
Mogilnicka E, Pile A. Rapid eye movement sleep deprivation inhibits clonidine-induced sedation in the rat. Europ J Pharmacol 1981; 71:123-126.
Mogilnicka E, Boissard CG, Hunn C. Suppresant effect of REM sleep deprivation on neophobia in normal rats and in rats with selective DSP-4 induced damage of locus coeruleus neurons. Pharmacol Biochem Behav 1985; 23:93-97.
Mollenhour MN, Voorhees JW, Davis SF. Sleepy and hostile: The effects of REM sleep deprivation on shock-elicited aggression. Anim Learn Behav 1977; 5:148-152.
Morrison A. Central active states overview. In: Beckman AL, ed. The neural basis of behavior. New York: Spectrum, 1982:3-18
Nofzinger EA, Reynolds III CF, Thase ME et al. American J Psychiatry 1995; 152:274-276.
Ogilvie RD, Broughton RJ. Sleep deprivation and measures of emotionality in rat. Psychophysiology 1976; 13:249-260.
51 Oniani T, Lortkipanidze L. Effect of paradoxical sleep deprivation on the learning and memory. In: Oniani TN, ed. Neurophysiology of motivation, memory and sleep-wakefulness cycle Tbilisi. Metzniereba: 1985:214-234
Perez NM, Benedito MAC. Activities of monoamine oxidase (MAO) A and В in discrete regions of rat brain after rapid eye movement (REM) sleep deprivation. Pharmacol Biochem Behav 1997; 58:605-608.
Piletz JE, Halaris A, Ernsberger PR. Psychopharmacology of imidazoline and alpha-2 adrenergic receptors: Implications for depression. Crit Rev Neurobiol 1994; 9:29-66.
Purcell S, Moffitt A, Hoffmann R. Waking, dreaming and self-regulation. In: Moffitt MA, Kramer R, Hoffmann, eds. The functions of dreaming. New York, Albany: State University of New York Press, 1993:197-260
Putkonen PTS. Alpha- and- beta-adrenergic mechanisms in the control of sleep stages. In: Priest RG, Pletscher A Ward J, eds. Sleep research: Proceedings of the Northern European Symposium on Sleep Research Basle. 1979:19-34.
Putkonen P, Putkonen A. Suppression of paradoxical sleep following hypothalamic defense reactions in cats during normal conditions and recovery from PS deprivation. Brain Res 1971; 6:334-347.
Putkonen PTS, Leppvuori A, Stenberg D. Paradoxical sleep inhibition by central alpha-2 adrenoreceptor stimulant, clonidine, antagonized by alpha-2 receptor blocker, yohimbine. Life Sciences 1977; 21:1059-1066.
Radulovacki M, Micovic N. Effects of REM sleep deprivation and desipramine on beta-adrenergic binding sites in rat brain. Brain Res 1982; 235:393-396.
Rasmussen K, Morilak DA, Jacobs BL. Single unit activity of locus coeruleus neurons in the freely moving cat. I. During naturalistic behavior and in response to simple and complex stimuli. Brain Res 1986; 371:324-334.
Rechtschaffen A, Gilliland M, Bergmann В et al. Physiological correlates of prolonged sleep deprivation in rats. Science 1983; 221:182-184.
Reynolds CF III, Kupfer D. Sleep in depression. In: Williams RZ, Karacan I, Moore CA, eds. Sleep disorders, diagnosis and treatment. New York: John Wiley, 1988:147-164.
Riemann D, Velthaus S, Laubenthal S et al. REM-suppressing effects of amitriptyline and amitriptyline N-oxide after acute medication in healthy volunteers: Results of two uncontrolled pilot trials. Pharmacopsychiatry 1990; 23:253-258.
Ross RJ, Ball WA, Gresh PJ et al. REM sleep suppression by monoamine reuptake blockade: Development of tolerance with repeated drug administration. Biol Psychiatry 1990; 28:231-239.
Ross RJ, Gresh PJ, Bull WA et al. REM sleep inhibition by desipramine: Evidence for an alpha-1- adrenergic mechanism. Brain Res 1995; 701:129-34.
Rotenberg VS. Search activity in the context of psychosomatic disturbances, of brain monoamines and REM sleep function. Pavlovian J Biolog Sci 1984; 19:1-15.
Rotenberg VS. The nature of nonlinear relationship between the individual's present state and his sleep structure. In: Koella W, Obal F, Schulz H, Visser P, eds. Sleep. Stuttgart and New York: Gustav Fischer Verlag, 1988a:86:134-137.
Rotenberg VS. Functional deficiency of REM sleep and its role in the pathogenesis of neurotic and psychosomatic disturbances. Pavlovian JO of Biological Science 1988b; 23:1-3.
Rotenberg V REM sleep and dreams as mechanism of search activity recovery. In: Moffitt A, Kramer M, Hoffmann R, eds. Function of Dreaming. New York: State University of New York press, 1993:261-292.
Rotenberg VS. The revised monoamine hypothesis: Mechanism of antidepressant treatment in the context of behavior. Integr Physiol Behav Sci 1994; 29:182-188.
Rotenberg VS. An integrative psychophysiological approach to brain hemisphere functions in schizophrenia. Neuroscience and Biobehavioral Reviews 1994; 18:487-495
Rotenberg VS. The psychobiological dream functions: A new solution for old contradiction. In: Rozenberg JJ, ed. Sense and Nonsense. Philosophical, clinical and ethical perspectives. The Magnes Press, the Hebrew University Jerusalem, 1996:187-197
Rotenberg VS. Learned helplessness and sleep: Discussion of contradictions. Homeostasis 1996; 37:89-92.
Rotenberg VS. Sleep after immobilization stress and sleep deprivation: Common features and theoretical integration. Critical Reviews in Neurobiology 2000; 14:225-231.
Rotenberg VS, Arshavsky W Search activity and its impact on experimental and clinical pathology. Activitas Nervosa Superior (Praha) 1979; 21:105-115.
Rotenberg VS, Arshavsky W Psychophysiology of hemispheric asymmetry: The "entropy" of right hemisphere activity. Integr Physiol Behav Sci 1991; 26:183-188.
Rotenberg VS, Boucsein W Adaptive versus maladaptive emotional tension. Genet Soc Gen Psychol Monographs 1993; 119:207-232.
Rotenberg VS, Sirota P, Elizur A. Psychoneuroimmunology: Searching for the main deteriorating psychobehavioral factor. Genet Soc Gen Psychol Monogr 1996; 122:329-346.
Rotenberg VS, Kayumov L, Indursky P et al. REM sleep in depressed patients: Different attempts to achieve adaptation. J Psychosomati Res 1997; 42:565-575.
Rotenberg VS, Shamir E, Barak Y et al. REM sleep latency and wakefulness in the first sleep cycle as markers of major depression. A controlled study vs. schizophrenia and normal controls. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2002; 26:1211-1215.
Sakai K. Some anatomical and physiological properties of pontomesencephalic tegmental neurons with special reference to the PGO waves and postural atonia during paradoxical sleep in the cat. In: Hobson JA, Brazier MA, eds. The Reticular Formation Revisited Raven. New York: 1980:427-447.
Salamone JD. The involvement of nucleus accumbens dopamine in appetitive and aversive motivation. Behav Brain Res 1994;,61:117-133.
Salamone JD, Cousins MS, Snyder BJ. Behavioral functions of nucleus accumbens dopamine: Empirical and conceptual problems with the anhedonia hypothesis. Neurosci Biobehav Rev 1997; 21:341-359.
Sastre JP, Sakai K, Jouvet M. Persistance du sommeil paradoxal chez le chat apres destruction de l'aire gigantocellulaire du tegmentum pontique par l'acide kainique. CR Acad Sci 1979; 289D:959-964.
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